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Free Cy5.5 dye and Cy5.5-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) have been routinely used for in vivo optical imaging. However, there is little information about the distribution and accumulation of free Cy5.5 dye and Cy5.5-labeled TCL-SPION in the tissues of mice.
Free Cy5.5 dye (0.1 mg/kg body weight) and Cy5.5-labeled TCL-SPION (15 mg/kg body weight) were intravenously injected into the tail vein of ICR mice. The biodistribution and accumulation of the TCL-SPION and Cy5.5 were observed by ex vivo optical imaging and fluorescence signal generation at various time points over 28 days. Saans me teri song download songs.pk.
The data were analysed using StatView 5.0 software (SAS Institute Inc.; Landau and Rabe-Hesketh, 1999).After the application of Kolmogorov-Smirnov's Test, which gives details about the Gaussian.
Cy5.5 dye fluorescence in various organs was rapidly eliminated from 0.5 to 24 h post-injection. Fluorescence intensity of Cy5.5 dye in the liver, lung, kidney, and stomach was fairly strong at the early time points within 1 day post-injection. Cy5.5-labeled TCL-SPION had the highest fluorescence density in the lung at 0.5 h post-injection and decreased rapidly over time. Fluorescence density in liver and spleen was maintained over 28 days. These results suggest that TCL-SPION can be useful as a carrier of therapeutic reagents to treat diseases by persisting for long periods of time in the body. Introduction Iron oxide nanoparticles, such as thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) and ultra SPION have been extensively studied for biomedical purposes due to their excellent biocompatibility [].
These particles are produced by a variety of synthesis processes ranging from traditional wet chemistry solution-based methods to more exotic techniques such as laser pyrolysis or chemical vapor deposition [,,]. In particular, the field of magnetic nanoparticle probe technology has been promoted by efforts devoted to developing its potential as a central tool for efficient, cross-application, molecular imaging [].
Many previous studies have been performed to investigate the potential of magnetic nanoparticles as drug delivery vehicles [,,,,,,]. The characteristic of magnetic nanoparticles makes them attractive for many applications ranging from contrast enhancing agents for magnetic resonance imaging (MRI) to drug delivery systems [,,]. SPION research has demonstrated that these nanoparticles may be an important tool for enhancing magnetic resonance contrast []. For this, the nanoparticles must have high magnetization values, a size smaller than 100 nm, and a narrow particle size distribution []. Magnetic nanoparticles have many advantages including laser-induced thermal therapy, the ability to target specific sites, and relatively low toxicity []. Biological applications of magnetic nanoparticles also need magnetic particles with peculiar surface coating that has to be nontoxic and biocompatible, and must permit targetable delivery with particle localization in a specific area.